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Preclinical and first-in-human of purinostat mesylate, a novel selective HDAC I/IIb inhibitor, in relapsed/refractory multiple myeloma and lymphoma
Amplifying antigen-induced cellular responses with proximity labelling
Microglia replacement halts the progression of microgliopathy in mice and humans
Chemotherapy awakens dormant cancer cells in lung by inducing neutrophil extracellular traps
Anti-BCMA CAR-T therapy in patients with progressive multiple sclerosis
Tumor-produced ammonia is metabolized by regulatoryT cells to further impede anti-tumor immunity
Tuning the sensitivity of mechanosensory receptors through histidine scanning
Single-Cell Multi-Omics Identifies Specialized Cytotoxic and Migratory CD8+ Effector T Cells in Acute Myocarditis
Single-cell RNA sequencing reveals a reprogramming of hepatic immune cells and a protective role for B cells in MASH-driven HCC
Integrated multi-omics identifies a CD54+ iCAF-ITGAL+ macrophage niche driving immunosuppression via CXCL8-PDL1 axis in cervical cancer
Tumor-associated macrophages promote chemoresistance to Paclitaxel via activating NOTCH2-JAG1 juxtacrine signaling
Molecular and immune correlates of response to first-line de-escalated chemotherapy plus penpulimab and anlotinib in advanced cervical cancer
Spatiotemporal Immune Determinants of Response to Immune Rechallenge in Advanced Cervical Cancer
Single‐cell sequencing reveals the role of IL‐33+ endothelial subsets in promoting early gastric cancer progression
Neoadjuvant immunotherapy driven bladder preservation for muscle invasive bladder cancer
Itaconate promotes inflammatory responses in tissue-resident alveolar macrophages and exacerbates acute lung injury
Single-cell and spatial transcriptomics reveal mechanisms of radioresistance and immune escape in recurrent nasopharyngeal carcinoma
Artesunate Nanoplatform Targets the Serine-MAPK Axis in Cancer-Associated Fibroblasts to Reverse hotothermal Resistance in Triple-Negative Breast Cancer
LPS-Binding Hydrogel for TLR4-Mediated Microbiota-Immune Modulation
Nociceptor-derived CGRP enhances dermal type I conventional dendritic cell function to drive autoreactive CD8+ T cell responses in vitiligo
Hypothesis-generating evaluation of multi-armoured oncolytic HSV-1 (VG161) in intrahepatic cholangiocarcinoma: pooled insights from multicentre studies
CD24 is a promising immunotherapeutic target for enhancing efficacy of third-generation EGFR-TKIs on EGFR-mutated lung cancer
Dual itaconate delivery systems modulate macrophage Acod1-Hif-1α-glycolysis axis for immunotherapy of bioprosthetic heart valve calcification
Spinal cord Tau pathology induces tactile deficits and cognitive impairment in Alzheimer’s disease via dysregulation of CCK neurons
Sexual dimorphism of lung immune-regulatory units imprint biased pulmonary fibrosis
Extracellular vesicles from antler blastema progenitor cells reverse bone loss and mitigate aging-related phenotypes in mice and macaques
USP20-Driven Cholesterol Metabolism Links Inflammatory Signaling to Malignancy and Stromal Co-evolution in Pancreatic Cancer
GUCY1A1-LDHA Axis Suppresses Ferroptosis in Cardiac Ischemia-Reperfusion Injury
Effect of Engineered Cyanobacterial Capsules on a Neurogenic Bladder after Spinal Cord Injury
Multi-Activity Nanozyme-Integrated Scaffolds: Harnessing Synergistic Enzyme-like Effects for Complete Treatment of Infected Bone Defects
MIF-mediated crosstalk between THRSP+ hepatocytes and CD74+ lipid-associated macrophages in hepatic periportal zone drives MASH
Tumor microenvironment heterogeneity and progression mechanisms in intrahepatic cholangiocarcinoma: A study based on single-cell and spatial transcriptomic sequencing
Efhcacy, safety and single-cell analysis of neoadjuvant immunochemotherapy in locally advanced oral squamous cel carcinoma: a phase I trial
Single-nucleus transcriptomics reveal the morphogenesis and artemisinin biosynthesis in Artemisia annua glandular trichomes
Metabolic support protects mucosa from ferroptosis in radiation-induced mucositis
Exercise-induced histone lactylation in monocyte-derived macrophages restores cardiac immune homeostasis and function in sepsis-induced cardiomyopathy
enascin C+ myofibroblasts exacerbate vascular neointimal hyperplasia by propagation of nerve-macrophage interactions in mice
Machine learning-enabled spatial multi-omics uncovers lactate-driven targets and tumor microenvironmental reprogramming in cancer
Globally patterned locus coeruleus-norepinephrine neuron-pericyte coupling orchestrates brain-wide vascular dynamics
Myeloid MAS–driven macrophage efferocytosis promotes resolution in ischemia-stressed mouse and human livers
Unraveling the Microenvironment and the Pathogenic Axis of HIF-1a–Visfatin–Fibrosis in Autoimmune Pancreatitis Using a Single-Cell Atlas
Mesencephalic Astrocyte-Derived Neurotrophic Factor Binds BAX to Preserve Mitochondrial Homeostasis and Energy Metabolism for Relieving Myocardial Hypertrophy
M2 Macrophage-Derived Extracellular Vesicles Reprogram lmmature Neutrophils into Anxalhi Neutrophils to Enhance Inflamed Bone Regeneration
The High-Altitude Adaptation Characteristics of Microbiota-Host Cross-Talk in Yak Gastrointestina Track
Smoking-Induced STC2+ Tumor Cells Drive Tumor-Vascular Crosstalk in Laryngeal Squamous Cell Carcinoma via Spatial and Single-Cell Transcriptomics
From Invaginating Site to Deep Lesion: Spatial Transcriptomics Unravels Ectopic Endometrial Penetration Features in Adenomyosis
Scale-Up ofHuman Amniotic Epithelial Cells Through Regulation ofEpithelial-Mesenchymal Plasticity Under Defined Conditions
dentification of a Force-Induced Sox9+Acan+ Transitional Subpopulation Linked to FGF2-FGFR2-ERK Signaling in Orthodontic Bone Remodeling
Identification and Mechanisms of Osteocyte Subsets Involved in the Pathological Progression of Osteoporosis
UBE2T-Driven p53 Degradation Rewires Glycolysis to Orchestrate Lactylation-Mediated CAFs Activation and ECM Deposition in Pancreatic Cancer
Targeting the CMKLR1-Mediated Signaling Rebalances Immunometabolism State in Middle-Age Testicular Macrophages
Pancancer Fine-Mapping of Mutational Intolerance Identifies CHEK1 as an Immunosuppressive Driver in Lung Adenocarcinoma
ZEB1 promotes chemo-immune resistance in pancreatic cancer models by downregulating chromatin acetylation of CXCL16
asxl1 C-terminal truncation and SRSF2 mutation drive leukemogenesis via immune reprogramming
Boosting mRNA cancer vaccine efficacy via targeting Irg1 on macrophages in lymph nodes
Luminal Stem-like Cells in High-Risk/Locally Advanced Prostate Cancer Promote Resistance to Hormonal Therapy
PTEN-mediated senescence of lung epithelial cells drives ventilator-induced pulmonary fibrosis
Pathogenomic analysis reveals clinically relevant epithelial-mesenchymal plasticity in esophageal squamous cell carcinoma
Spatial multi-omics guides ASCT2-targeted delivery of glycolysis inhibitor for cervical cancer suppression and chemoresistance reversal
Illustrating the functional heterogeneity of M-MDSCs to predict sepsis outcomes
Biomimetic phosphorus dendrimer multi epitope nanovaccine enhances humoral and cellular immune response against African swine fever virus
Human adipose-derived mesenchymal stem cell-derived exosomes induce epithelial remodeling and anti-scar healing revealed by single-cell RNA sequencing | Journal of Nanobiotechnology
Targeting tumor-associated CCR2+ macrophages to inhibit pancreatic cancer recurrence following irreversible electroporation
Breast cancer induces CD62L+ Kupffer cells via DMBT1 to promote neutrophil extracellular trap formation and liver metastasis
BCMA/CD19 CAR T cell therapy for refractory myasthenia gravis: Proteomic signatures and single-cell transcriptomics of disease flares
Single-cell transcriptomics identifies PDGFRA+ progenitors orchestrating angiogenesis and periodontal tissue regeneration
Anti-BCMA CAR-T cell therapy in relapsed/refractory chronic inflammatory demyelinating polyneuropathy
Integrating single-cell RNA sequencing and spatial multi-omics reveals the molecular signature of regeneration after spinal cord injury
Skeletal muscle-derived lL-33 mediates muscle-to-bone crosstalk and regulates bone metabolism via CD8 T cell-secreted CCL5
Neonatal-Inspired Reprogramming of Microglial Pan-Programmed Cell Death Enhances Regeneration in Adult Spinal Cord Injury
Spatial Transcriptional Heterogeneity in the Infarct Core and Its Surrounding Regions Targeting Piezo1 Signals in Rats With Myocardial Ischemia-Reperfusion Injury
Ce6 derivative photodynamic therapy triggers PANoptosis and enhances antitumor immunity with LAG3 blockade in cutaneous squamous cell carcinoma
High cellular plasticity state of medulloblastoma local recurrence and distant dissemination
Interferon-driven CAF reprogramming augments immunogenic response to neoadjuvant radiotherapy in colorectal cancer
Mass Spectrometry Imaging Combined with Single-Cell Transcriptional Profiling Reveals the Multidimensional Spatial Distributions and Biosynthetic Pathways of Medicinal Components in Andrographis paniculata
Immunodynamic axis of fbroblast-driven neutrophil infltration in acute pancreatitis: NF-κB–HIF-1α–CXCL1
Itaconate Modulates Neutrophil Homeostasis to Ameliorate Airway Inflammation in Diesel Exhaust Particles-exacerbated Asthma via Inhibiting NETs Formation
Disruption of bile acid homeostasis potentiates Paneth cell ablation by activating the intestinal Farnesoid X receptor in necrotizing enterocolitis
Disruption of bile acid homeostasis potentiates Paneth cell ablation by activating the intestinal Farnesoid X receptor in necrotizing enterocolitis_copy20260314125136Setdb1 ablation in macrophages attenuates fibrosis in heart allografts
Blood-abyrinth barrier damage mediated by granzymes from cytotoxic lymphocytes results in hearing loss in systemic lupus erythematosus
Spatially resolved multiomics reveals the self-enforcing property of the leading-edge multicellular ecosystem of head and neck cancer
Single-cell transcriptomics reveals extracellular matrix remodeling and collagen dynamics during lactation in sheep mammary gland
Spatiotemporally transcriptomic analyses of floral buds reveal the high-resolution landscape of flower development and dormancy regulation in peach
Dalbergia odorifera T.C. Chen Leaf Extract Promotes Microglial Energy Expenditure to Phagocytize Neutrophils After Cerebral Ischemia-reperfusion
ECT2+ cell group acts as cancer stem cell in malignant pleomorphic adenoma
A dynamic molecular landscape in colorectal cancer progression at single-cell resolution
Spatial multi-omics profiling uncovers metabolic heterogeneity in Sjögren’s syndrome and identifies PS(36:1) as a potential therapeutic target
Spatial Transcriptomic characteristics of the Aging Human ovary
Single-nucleus profiling of mouse inner ear aging uncovers cell type heterogeneity and hair cell subtype-specific age-related signatures
Periodontitis Induces Arterial Microbiota Shifts and Immune Dysregulation Contributing to Peripheral Vascular Inflammation
Dissecting the development of bovine testicular tissue using spatial transcriptomics
Single‐Cell RNA Sequencing Reveals the Developmental Landscape of Wheat Roots
Single-cell sequencing combined with spatial transcriptomics reveals the characteristics of follicle-targeted inflammation patterns in primary cicatricial alopecia
Unveiling the development of cotton somatic embryos: Integrating spatial transcriptomics and metabolomics
Schwann Cell-Secreted S100B Promotes Wound Healing via Paracrine Modulation
Decoding Spatiotemporal Microenvironmental Changes in Oral Carcinogenesis
Humoral immune activation within tertiary lymphoid structures is correlated with poor outcomes in oral lichen planus and lichenoid lesions
Single-cell RNA sequencing reveals T and B cell related immune features in foot and mouth disease virus-infected mice
Single-Cell RNA Sequencing Reveals Granzyme K+ CD8+ T Cells as a Target for Mitigating Plaque Instability Following Radiation
The landscape of cell regulatory and communication networks in the human dental follicle
The integration of spatial transcriptomics and metabolic data from the cortical region of the brain identifies key genes associated with cognitive ability in pigs
Single-cell transcriptional decoding of iron deficiency responses in maize root tips
Spatial metabolomics and transcriptomics reveal cell type-specific dynamics in the placenta of patients with late-onset preeclampsia
Single-cell RNA-seq reveals the immune profile changes in patients with diarrhoeal-irritable bowel syndrome
CRISPR/Cas9-mediated SHP-1-knockout T cells combined with simvastatin enhances anti-tumor activity in humanized-PDX HCC model
Integrated spatial omics of metabolic reprogramming and the tumor microenvironment in pancreatic cancer
Intestinal epithelial formyl peptide receptor 2 contributes to intestinal epithelium homeostasis and injury repair by regulating intestinal stem cell and transit-amplifying cell proliferation and differentiation
A wheat tandem kinase activates an NLR to trigger immunity
A kinase mediator of rhizobial symbiosis and immunity in Medicago
Nature
Releasing a sugar brake generates sweeter tomato without yield penalty
Yeast Library
2024
Plant
Science
Enhanced sustainable green revolution yield via nitrogen-responsive chromatin modulation in rice
Yeast Library
2020
Plant
ScienceNature Plants
MdBT2 regulates nitrogen-mediated cuticular wax biosynthesis via a MdMYB106-MdCER2L1 signalling pathway in apple
Yeast Library
2024
Plant
Nature Communications
Transfer learning enables identification of multiple types of RNA modifications using nanopore direct RNA sequencing
Yeast Library
2024
Plant
Plant Biotechnology Journal
PagARGOS promotes low-lignin wood formation in poplar
Yeast Library
2024
Plant
Nature
Oncolytic virus VG161 in refractory hepatocellular carcinoma
10x Genomics Single Cell Sequencing
10 x Genomics Spatial Transcriptomics Sequencing
2025
Oncology
Human
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  • Germany: Arnold-Graffi-Haus / D85 Robert-Rössle-Straße 10  13125 Berlin

    United States: (CA) 2 Goddard, Irvine, CA 92618 

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    Hong Kong: Room 618, Building 6, Hong Kong Science Park, Pak Shek Kok, Hong Kong

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